Detection of protective antibodies and seroconversion after SARS-CoV-2 infection or vaccination can help guide patient care plans and public health policies. IMPORTANCE Serological surveillance has become an important public health tool during the COVID-19 pandemic. The accuracy, adaptability, and cost-effectiveness of this test make it an excellent option for clinical deployment in the ongoing COVID-19 pandemic. We further show that this sensitive test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual’s immune response. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. A key component of COVID-19 control efforts is serological testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior SARS-CoV-2 infection or vaccination. The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to place an immense burden on societies and health care systems. Lai, Kartik Chandran Show Fewer Authors Info & Affiliations Szymczak, Karen Tong, Jason Barnhill, Mattias N. Mariano, Antonio Nakouzi, Jose Quiroz, Johanna Rivera, Wendy A. Jangra, Alev Celikgil, Duncan Kimmel, James H. Maximilian Fels, Denise Haslwanter, Rohit K. Georgiev, Show All (41 Authors), Olivia Vergnolle, Natalia G. Bortz III, Catalina Florez, Ethan Laudermilch, Ariel S.
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